Name: Wang Kun

Subject: Developmental Biology

Tel/Fax: +86-532-82991791  /  +86-532-82991791

E-mail: wangk696@qdu.edu.cn

Address: Institute for Translational Medicine, Qingdao University, Qingdao, Shandong, 100101, P.R.China

Resume:

Wang Kun is currently a professor at Qingdao University and director of the Developmental Cardiology Center of the Institute of Translational Medicine, Qingdao University. Winner of the 2015 "National Outstanding Youth Fund", 2016 "Shandong Natural Science Outstanding Youth Fund", 2016 "Taishan Scholar Young Expert". She has been engaged in the study of molecular mechanisms of heart and cardiovascular diseases for many years, and her main research directions include: the study of signal pathways and molecular mechanisms of cardiomyocyte hypertrophy, necrosis, apoptosis and cardiomyocyte autophagy; explore the intervention and treatment of non-coding RNA and gene-related heart diseases; the molecular mechanism of cardiomyocyte proliferation and cardiac regeneration. So far, research results have been published in internationally renowned journals such as Nature Cell Biology, Circulation, European heart journal, Circulation Research, Nature communications. The research results obtained eight national invention patents.

Research Interests:

Prof. Wang’s research interests cover basic research and application of cardiomyocyte signaling pathway.

Selected Publications:

1.Gao XQ#, Zhang YH#, Liu F#, Ponnusamy M#, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K*. The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N 6-methyladenosine methylation of Parp10 mRNA. (2020) Nature cell biology 22(11):1319-1331. doi: 10.1038/s41556-020-0576-y.

2.Ponnusamy M#; Liu F#; Zhang YH#; Li RB#; Zhai M; Liu F; Zhou LY; Liu CY; Yan KW; Dong YH; Wang M; Qian LL; Shan C; Xu S; Wang Q; Zhang YH; Li PF; Zhang J*; Wang K*. Long Noncoding RNA CPR (Cardiomyocyte Proliferation Regulator) Regulates Cardiomyocyte Proliferation and Cardiac Repair. (2019) Circulation 139:2668-2684. doi: 10.1161/ CIRCULATIONAHA.118.035832

3.Liu CY#, Zhang YH#, Li RB#, Zhou LY#, An T, Zhang RC, Zhai M, Huang Y, Yan KW, Dong YH, Ponnusamy M, Shan C, Xu S, Wang Q, Zhang YH, Zhang J, Wang K*. LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription. Nature communications. 2018;9:29 doi: 10.1038/s41467-017-02280-y.

4.Wang K*, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF*. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. (2016) European Heart Journal 37(33):2602-11 doi: 10.1093/eurheartj/ehv713.

5.Wang K, Zhou LY, Wang JX, Wang Y, Sun T, Zhao B, Yang YJ, An T, Long B, Li N, Liu CY, Gong Y, Dong YH, Zhang J*, Li PF*. E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1. Nature Communications. 2015 Jul 17;6:7619

6.Wang K#, Liu F#, Zhou LY#, Long B, Yuan SM, Wang Y, Liu CY, Sun T, Zhang XJ, Li PF*. The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489. Circulation Research. 2014;Apr 25;114(9):1377-88