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讲师:张媛

2016年09月27日 15:47  点击:[]

张媛,女,1984年出生,博士,讲师。

2014年毕业于吉林大学,获得生物化学与分子生物学博士;2015年进入青岛大学医学部工作。博士期间主要研究方向为蛋白质的功能调节与神经损伤和修复,主要针对运用免疫疗法及小分子抗体药物进行预防和治疗阿尔茨海默病的相关研究。

曾参与吉林省科技发展计划项目《针对老年痴呆中Aβ42靶点的单链抗体的研究》,为项目主要参与人;发表SCI论文多篇,累积影响因子IF>12;申请国家发明专利2项。

研究方向

1. 阿尔茨海默病发病机制研究

2. 小分子抗体药物研究

代表论文:

1. Yuan Zhang#, Xu Chen, Jinyu Liu, Yingjiu Zhang*. The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody.Neuropharmacology. 2015, 99:387-395.

2. Yuan Zhang#, Yuanhong Sun, Yangyang Huai, Yingjiu Zhang*. Functional characteristics and molecular mechanism of a new scFv antibody against Aβ42 oligomers and immature protofibrils.Molecular Neurobiology. 2015, 52(3):1269-81.

3. Zhang Yuan#, Zou Wei*, Cui Fenggong, Wang Nan, Zhang Dongyan, Cui Yuying, Liu Peng, Liu Jing. Protective effect of phosphatidylcholine on restoration of ethanol-injured hepatocytes related with caveolin-1.J Membr Biol.2014, 247(1):73-80.

4. Ying Liu#, Dongdong Chen, Yongheng Xing, Nan Ge,Yuan Zhang, Jing Liu, Wei Zou*. A new oxovanadium complex enhances renal function by improving insulin signaling pathway in diabetic mice.J Diabetes Complications.2014.

5. Liyan Lei#, Guangji Zhang, Pengfei Li,Yuan Zhang, Youming Guo, Wenqi Zhang, Wenbo Zhang, Bing Hua, Liping Wang*. DhHP-3 mitigates the symptoms of rats with non-insulin dependent diabetes mellitus by protecting pancreatic β-cells against glucotoxicity through scavenging reactive oxygen species and activating the PI3-K/AKT signal transduction pathway.Chemico-Biological Interactions. 2014, 220:64.74.

6. Lili Cui#,Yuan Zhang, Hao Cao, Yan Wang, Teng Teng, Guoda Ma, You Li, Keshen Li, Yingjiu Zhang*. Ferulic acid inhibits the transition of amyloid-β42 monomers to oligomers but accelerates the transition from oligomers to fibrils.Journal of Alzheimer’s Disease. 2013. 37:19-28.

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