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讲师:刘英

2016年09月27日 15:47  点击:[]

刘英,男,1982年出生,博士,讲师。

2015年毕业于大连理工大学生命科学与技术学院;同年进入青岛大学转化医学研究院工作。首次发现了插头蛋白转录因子FOXK2和雌激素受体ERα在乳腺癌中的表达呈负相关。FOXK2能够和ERα相互作用,下调ERα的蛋白水平,并抑制其转录活性,进而抑制乳腺癌细胞的增殖。本研究对阐述ERα介导的乳腺癌发生发展的分子机理具有重要意义,也为ERα介导的疾病的治疗开辟了新思路,并以第一作者的身份将研究成果发表(Liu et al.Scientific Reports. 2015);

现参与国家自然科学基金等国家级科研项目5项;发表SCI论文10篇,影响因子累计37.536,其中以第一作者(含共同第一作者)身份在Scientific Reports(影响因子5.578)等杂志发表SCI论文3篇,累计影响因子10.894;;获2015年度大连市自然科学优秀学术论文一等奖、2013年度大连市科学技术奖励一等奖。

研究方向

1. 蛋白质翻译后修饰研究与肿瘤发生发展的分子机制

2. 基因组表观遗传学研究

3. 干细胞分化的研究

代表论文:

1.Ying Liu#, Xiang Ao#, Zhaojun Jia, Xiaoyan Bai, Zhaowei Xu, Gaolei Hu, Xiao Jiang, Min Chen, and Huijian Wu. FOXK2 Transcription Factor Suppresses ERα-positive Breast Cancer Cell Growth Through Down-Regulating the Stability of ERα via mechanism involving BRCA1/BARD1.Scientific Reports, 2015,5:8796. doi: 10.1038/srep08796.

2.Ying Liu,Dongdong Chen, Yongheng Xing, Nan Ge, Yuan Zhang, Jing Liu, Wei Zou. A new oxovanadium complex enhances renal function by improving insulin signaling pathway in diabetic mice.J Diabetes Complications.2014, doi:10.1016/j.jdiacomp.2014.02.001.

3.Xiang Ao#,Ying Liu#,Huijian Wuet al.Association betweenEHBP1rs721048(A>G) polymorphism and Prostate Cancer Susceptibility: A Meta-Analysis of 17 Studies Involving 150,678 Subjects.OncoTargets and Therapy,2015.

4.Feng Zhao#, Miao Wang#, Shujing Li, Xiaoyan Bai, Hailian Bi,Ying Liu,et al. DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis.Oncogenesis, 2015, 16;4:e143.

5.Chunhua Yang,Shujing Li, Miao Wang, Alan K Chang,Ying Liuet al.PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.Mol Cancer2013, 12:21.

6.Hongming Pan#, Wenquan Niu#, Lan He, Bin Wang, Jun Cao, Feng Zhao,Ying Liu,et al. Contributory role of five common polymorphisms ofRAGEandAPE1genes in lung cancer among han chinese.PLoS ONE. 2013, 11;8(7):e69018.

7.Shujing Li,Chunhua Yang,Yongde Hong, Hailian Bi, Feng Zhao,Ying Liu,et al. The transcriptional activity of coactivator AIB1 is regulated by the SUMO E3 ligase PIAS1.Biol Cell, 2012, 104(5): 287-296.

8.Shujing Li,Miao Wang,Xiang Ao, Hailian Bi, Alan K. Chang,Chunhua Yang,Feng Zhao,Ying Liu,et al.CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptorα.Oncogene,2012, 1-9.

9.Yongde Hong#, Xinrong Xing#,Shujing Li,Hailian Bi, Chunhua Yang, Feng Zhao,Ying Liu,et al. SUMOylation of DEC1 Protein Regulates Its Transcriptional Activity and Enhances Its Stability.PLoS ONE. 2011, 6(8): e23046.

10.Dongdong Chen, Huifang Huang, Yongheng Xing,Ying Liu,et al. A new vanadium complex improves the spatial learning and memory by activation of caveolin-MAPK-CREB pathway in diabetic mice.J Diabete Metab. 2011, 2(1): 1000114.

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