王昆,博士,青岛大学特聘教授,博士生导师,青岛大学转化医学研究院发育心脏病学中心主任。2015年国家优秀青年基金获得者,2016年山东省自然科学杰出青年基金获得者,2016年“泰山学者青年专家”称号获得者,2018年科技部“中青年科技创新领军人才”称号获得者。
多年来从事心脏及心血管疾病分子机制的研究,在心肌细胞肥大、凋亡、坏死、自噬等细胞生物学领域取得了一系列重大进展,在学术界产生很大影响;在非编码RNA、线粒体分裂机制与心血管疾病发病机理方面处于国际领先水平。
目前为止,在European heart journal 、Circulation 、Circulation Research 、Nature communications、Molecular Cell、Gene & Development、PNAS、Cell Death & Differentiation、PLoS Genetics、Cell Death & Disease等国际著名期刊上发表SCI论文47篇,其中影响因子大于10的13篇,2篇文章入选ESI高被引论文;1篇论文入选中国百篇最具影响国际学术论文;1篇被F1000推荐。文章发表后被Cell等SCI杂志引用2037次。获国家发明专利5项。
研究方向
1. 心肌细胞自噬及坏死的分子机制研究
2. 心肌细胞肥大及凋亡的信号通路及分子机制研究
3. 探讨与非编码RNA和基因相关的心脏疾病的干预治疗方法
4. 心脏线粒体动力学的分子机制
5. 心肌干细胞与心肌细胞再生
代表论文:(#第一作者,*通讯作者)
1. Murugavel Ponnusamy, Fang Liu, Yu-Hui Zhang, Rui-Bei Li, Mei Zhai, Fei Liu, Lu-Yu Zhou, Cui-Yun Liu, Kao-Wen Yan, Yan-Han Dong, Man Wang, Li-Li Qian, Chan Shan, Sheng Xu, Qi Wang, Yan-Hui Zhang, Pei-Feng Li, Jian Zhang, Kun Wang*. Long Noncoding RNA CPR (Cardiomyocyte Proliferation Regulator) Regulates Cardiomyocyte Proliferation and Cardiac Repair.Circulation.2019 Jun 4;139 (23), 2668-2684.
2. Cui-Yun Liu, Yu-Hui Zhang, Rui-Bei Li, Lu-Yu Zhou, Tao An, Rong-Cheng Zhang, Mei Zhai, Yan Huang, Kao-Wen Yan, Yan-Han Dong, Murugavel Ponnusamy, Chan Shan, Sheng Xu, Qi Wang, Yan-Hui Zhang, Jian Zhang, Kun Wang*. LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription.Nature Communications.2018 Jan 2; 9 (1), 29.
3. Wang K#,*,Long B#, Liu F#, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF*. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223.Eur Heart J. 2016 Jan 21; pii: ehv713.
4. Kun Wang, Lu-Yu Zhou, Jian-Xun Wang, Yin Wang, Teng Sun, Bing Zhao, Yong-Jie Yang, Tao An, Bo Long, Na Li, Cui-Yun Liu, Ying Gong, Jin-Ning Gao, Yan-Han Dong, Jian Zhang, Pei-Feng Li. E2F1-dependent miR-421 Regulates Mitochondrial Fragmentation and Myocardial Infarction by Targeting Pink1.Nature Communications. 2015 Jul 17; 6, 7619.
5. Wang K, Liu CY, Zhou LY, Wang JX, Wang M, Zhao B, Zhao WK, Xu SJ, Fan LH, Zhang XJ, Feng C, Wang CQ, Zhao YF, Li PF*.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p.Nature Communications.2015;Apr 10;6:6779.
6. Wang K, Long B, Zhou LY, Liu F, Zhou QY, Liu CY, Sun T, Fan YY,Li PF*.CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation.Nature Communications.2014;Apr 7;5:3596.
7. Wang K, Liu F#, Zhou LY#, Long B, Yuan SM, Wang Y, Liu CY, Sun T, Zhang XJ,Li PF*.The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489.Circulation research.2014;Apr 25;114(9):1377-88.
8. Wang K, Long B, Jiao Jian JQ, Wang JX, Liu JP, Li Q, Li PF*. MiR-484 regulates mitochondrial network through targeting Fis1.Nature Communications.2012;Apr 17;3:781.