特聘教授：王曼

王曼，女，博士，副教授。

 

2014年毕业于武汉大学，同年进入青岛大学医学部工作，2019年入选青岛大学第五层次特聘教授。主持国家自然科学基金青年项目1项，山东省自然科学基金项目（博士基金）1项，中国博士后科学基金面上项目1项和青岛市源头创新计划应用基础研究项目1项；参与国家自然科学基金重点项目和面上项目等7项。共发表SCI论文28篇，其中以第一作者或通讯作者身份在《Applied Microbiology and Biotechnology》，《Cellular and Molecular Life Sciences》，《Frontiers in Immunology》，《Cancers》和《International Journal of Biological Sciences》等杂志上发表SCI论文17篇。

 

研究方向

1. 抗病毒疫苗筛选及其免疫保护机制研究

2. 细胞自噬在疱疹病毒感染和致病中的作用机制研究

3. 非编码RNA高通量测序及数据分析

4. 非编码RNA在肝癌发展中的作用机制研究

 

代表论文：(#第一作者，*通讯作者)

1. Wang M*, Gu B, Chen X, Wang Y, Li P and Wang K*. 2019. The function and therapeutic potential of Epstein-Barr virus-encoded microRNAs in cancer. Molecular Therapy-Nucleic Acids. 17:657-668. 

2. Wang M*, Jiang S, Zhang Y, Li P and Wang K*. 2019. The multifaceted roles of pyroptotic cell death pathways in cancer. Cancers. 11(9): 1313.

3. Wang M*, Yu F, Ding H, Wang Y, Li P, Wang K*. 2019. Emerging function and clinical values of exosomal microRNAs in cancer. Molecular Therapy-Nucleic Acids. 16:791-804.

4. Wang M*, Zhou L, Yu F, Zhang Y, Li P, Wang K*. 2019. The functional roles of exosomal long non-coding RNAs in cancer. Cellular and Molecular Life Sciences. 76(11):2059-2076.

5. Wang M*, Jiang S, Zhou L, Yu F, Ding H, Li P, Zhou M, Wang K*. 2019. Potential mechanisms of action of curcumin for cancer prevention: focus on cellular signaling pathways and miRNAs. International Journal of Biological Sciences. 15(6):1200-1214.

6. Wang M*, Jiang S, Yu F, Zhou L, Wang K*. 2019. Noncoding RNAs as molecular targets of resveratrol underlying its anticancer effects. Journal of Agricultural and Food Chemistry. 67(17):4709-4719.

7. Wang M*, Jiang S, Wu W, Yu F, Chang W, Li P, Wang K*. 2018. Non-coding RNAs function as immune regulators in teleost fish. Frontiers in Immunology. 9:2801.

8. Wang M, Yu F, Li P*. 2018. Circular RNAs: characteristics, function and clinical significance in hepatocellular carcinoma. Cancers. 10(8): 258.

9. Wang M*, Yu F, Wu W, Wang Y, Ding H, Qian L. 2018. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. International Journal of Biological Sciences. 14(5):565-576.

10. Wang M*, Wu W, Zhang Y, Yao G, Gu B. 2018. Rapamycin enhances lytic replication of Epstein-Barr virus in gastric carcinoma cells by increasing the transcriptional activities of immediate-early lytic promoters. Virus Research. 244:173-180.

11. Wang M, Yu F, Wu W, Zhang Y, Chang W, Ponnusamy M, Wang K*, Li P*. 2017. Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity. International Journal of Biological Sciences. 13(12):1497-1506.

12. Wang M*, Jiang S, Zhou L, Wang C, Mao R, Ponnusamy M. 2017. Efficient production of recombinant glycoprotein D of herpes simplex virus type 2 in Pichia pastoris and its protective efficacy against viral challenge in mice. Archives of Virology. 162(3):701-711.

13. Wang M*, Jiang S, Wang Y. 2016. Recent advances in the production of recombinant subunit vaccines in Pichia pastoris. Bioengineered. 7(3):155-165.

14. Wang M*, Jiang S, Han Z, Zhao B, Wang L, Zhou Z, Wang Y*. 2016. Expression and immunogenic characterization of recombinant gp350 for developing a subunit vaccine against Epstein-Barr virus. Applied Microbiology and Biotechnology. 100(3):1221-1230.

15. Wang M, Jiang S, Liu X, Wang Y*. 2013. Expression, purification, and immunogenic characterization of Epstein-Barr virus recombinant EBNA1 protein in Pichia pastoris. Applied Microbiology and Biotechnology. 97(14):6251-6262.

16. Wang M^#, Gu B^#, Huang J^#, Jiang S, Chen Y, Yin Y, Pan Y, Yu G, Li Y, Wong BH, Liang Y, Sun H*. 2013. Transcriptome and proteome exploration to provide a resource for the study of Agrocybe aegerita. PLoS One. 8(2):e56686. 

17. Wang T, Zhai M, Xu S, Ponnusamy M, Huang Y, Liu C, Wang M, Shan C, Shan P, Gao X, Wang K, Chen X, Liu J, Xie J, Zhang D, Zhou L*, Wang K*. 2020. NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression. Theranostics. 10(2):553-566.

18. Yu F, Abdelwahid E*, Xu T, Hu L, Wang M, Li Y, Mogharbel BF, de Carvalho KAT, Guarita-Souza LC, An Y*, Li P*. 2019. The role of mitochondrial fusion and fission in the process of cardiac oxidative stress. Histology and Histopathology. 10:18191.

19. Ponnusamy M, Liu F, Zhang Y, Li R, Zhai M, Liu F, Zhou L, Liu C, Yao K, Dong Y, Wang M, Qian L, Shan C, Xu S, Wang Q, Zhang Y, Li P, Zhang J*, Wang K*. 2019. Long noncoding RNA CPR (cardiomyocyte proliferation regulator) regulates cardiomyocyte proliferation and cardiac repair. Circulation. 139(23):2668-2684.

20. Yu F, Xu T, Wang M, Chang W, Li P*, Wang J*. 2018. Function and regulation of mitofusin 2 in cardiovascular physiology and pathology. European Journal of Cell Biology. 97(7):474-482.

21. Mao R, Wu D, Hu S, Zhou K, Wang M, Wang Y*. 2017. Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria. Applied Microbiology and Biotechnology. 101(8): 3259-3271.

22. Wang K^#*, Long B^#, Liu F^#, Wang J, Liu C, Zhao B, Zhou L, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong Y, Li N, Li P*. 2016. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. European Heart Journal. 37(33):2602-2611.

23. Wang K, Liu C, Zhou L, Wang J, Wang M, Zhao B, Zhao W, Xu S, Fan L, Zhang X, Feng C, Wang C, Zhao Y, Li P*. 2015. APF lncRNAregulates autophagy and myocardial infarction by targeting miR-188-3p. Nature Communications. 6: 6779.