常文光,女,博士,讲师。
2013年在吉林大学白求恩医学院获得药理学博士学位,同年赴加拿大Manitoba大学医学院做博士后研究,2015年12月回国。2016年进入青岛大学转化医学研究院工作。主要从事内分泌药理及心血管分子药理的研究,对心肌缺血再灌注,心力衰竭,脑缺血再灌注以及糖尿病心肌病的发病机制和药物治疗以及糖尿病相关磷脂和中性脂质的合成和代谢方面有较深入研究。参加过多个国家自然科学基金以及省级科研项目。共发表学术论文26篇,其中SCI收录论文25篇。
研究方向
1.糖尿病研究
2.心血管研究
3.内分泌疾病和心血管疾病动物模型
4.中性脂质代谢和磷脂代谢机制研究
代表论文:(#第一作者,*通讯作者)
1. Wenguang Chang*, Hongge Fa, Dandan Xiao, Jianxun Wang. MicroRNA-184 alleviates insulin resistance in cardiac myocytes and high fat diet-induced cardiac dysfunction in mice through the LPP3/DAG pathway. Mol Cell Endocrinol. 2020 May 15; 508:110793.
2. Wenguang Chang*, Jianxun Wang*. Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus. Cells. 2019 Aug 8;8(8).
3. Wenguang Chang*, Dandan Xiao, Xiang Ao, Mengyang Li, Tao Xu, Jianxun Wang*. Increased Dynamin-Related Protein 1-Dependent Mitochondrial Fission Contributes to High-Fat-Diet-Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts. Molecular Nutrition and Food Research. 2019 Jan 10: e1801322.
4. Wenguang Chang*. Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities. European Journal of Pharmacology. 2017, Jan 15, 795:8-12.
5. Wenguang Chang, Li Chen, Grant M. Hatch*. Berberine treatment attenuates palmitate-induced insulin resistance through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes. Biochimica et Biophysica Acta-molecular and cell biology of lipids.2016, 7;1861(4):352-362.