卓越人才：张德玖

张德玖 ，男，博士，讲师

研究方向：蛋白质翻译调控

电子邮件（E-mail）dejiuzhang@hotmail.com

2010.09 -2016.07  中国科学院大学 生物物理所  生物化学与分子生物学  理学博士

2016.07-2019.07中国科学院生物物理研究所 助理研究员

2019.08-至今，青岛大学转化医学研究院

研究方向

以“细胞内的核糖体结构与功能”为科学问题开展课题，研究翻译起始与延伸的分子机制，以及这两个过程中tRNA的选择机理。

代表性论文

1. Gao, Y., Bai, X., Zhang, D.J., Han, C., Yuan, J., Liu, W., Cao, X., Chen, Z., Shangguan, F., Zhu, Z., et al. (2016). Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis. Nature structural & molecular biology 23(5): 441-449..

2. Zhang, D.J., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Lou, J., et al. (2016). EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. Nature structural & molecular biology 23, 125-131.

3. Zhang, D.J., Yan, K., Zhang, Y., Liu, G., Cao, X., Song, G., Xie, Q., Gao, N., and Qin, Y. (2015). New insights into the enzymatic role of EF-G in ribosome recycling. Nucleic acids research 43, 10525-10533.

4. Zhang, Y., Mandava, C.S., Cao, W., Li, X., Zhang, D.J., Li, N., Zhang, Y., Zhang, X., Qin, Y., Mi, K., et al. (2015). HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions. Nature structural & molecular biology 22, 906-913.

5. Liu, G., Song, G., Zhang, D., Zhang, D.J., Li, Z., Lyu, Z., Dong, J., Achenbach, J., Gong, W., Zhao, X.S., et al. (2014). EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex. Nature structural & molecular biology 21, 817-824.

6. Zhang, D.J., and Qin, Y. (2013). The paradox of elongation factor 4: highly conserved, yet of no physiological significance? The Biochemical journal 452, 173-181.

7. Wang, L., Yang, F., Zhang, D.J., Chen, Z., Xu, R.M., Nierhaus, K.H., Gong, W., and Qin, Y. (2012). A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nature structural & molecular biology 19, 403-410.

8. Tang, X.L., Yue, F., Yan, X.F., Zhang, D.J., Xin, Y., Wang, C., and Chen, Q. (2012). Effects of gestation temperature on offspring sex and maternal reproduction in a viviparous lizard (Eremias multiocellata) living at high altitude. Journal of Thermal Biology 37, 438-444.

9. Tang, X.L., Yue, F., Zhang, D.J., Yan, X.F., Xin, Y., Wang, C., and Chen, Q. (2012). The effect of operational sex ratio on sex allocation and neonate phenotype in a viviparous lizard Eremias multiocellata. Amphibia-Reptilia 33, 485-493.

10. Xin, Y., Tang, X., Yue, F., Zhang, D.J., Yan, X., Wang, C., and Chen, Q. (2012). Isolation and sequence analysis of sox genes from lizard Eremias multiocellata. Genetika 48, 89-96.

11. Yue, F., Tang, X.L., Zhang, D.J., Yan, X.F., Xin, Y., and Chen, Q. (2012). Body temperature and standard metabolic rate of the female viviparous lizard Eremias multiocellata during reproduction. Canadian Journal of Zoology 90, 79-84.

12. Yan, X.F., Tang, X.L., Yue, F., Zhang, D.J., Xin, Y., Wang, C., and Chen, Q. (2011). Influence of ambient temperature on maternal thermoregulation and neonate phenotypes in a viviparous lizard, Eremias multiocellata, during the gestation period. Journal of Thermal Biology 36, 187-192.

13. Zhang, D.J., Tang, X.L., Yue, F., Chen, Z., Li, R.D., and Chen, Q. (2010). Effect of gestation temperature on sexual and morphological phenotypes of offspring in a viviparous lizard, Eremias multiocellata. Journal of Thermal Biology 35, 129-133.