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卓越人才:常文光

2016年09月27日 15:47  点击:[]

常文光,女,1986年出生,博士,讲师。

2013年在吉林大学白求恩医学院获得药理学博士学位,同年赴加拿大Manitoba大学医学院做博士后研究,2015年12月回国。2016年进入青岛大学转化医学研究院工作。主要从事内分泌药理及心血管分子药理的研究,对心肌缺血再灌注,心力衰竭,脑缺血再灌注以及糖尿病心肌病的发病机制和药物治疗以及糖尿病相关磷脂和中性脂质的合成和代谢方面有较深入研究。参加过多个国家自然科学基金以及省级科研项目。共发表学术论文10篇,其中SCI收录论文9篇,第一作者SCI收录论文6篇,影响因子累计20余分。

研究方向

1.糖尿病研究

2.心血管研究

3.内分泌疾病和心血管疾病动物模型

4.中性脂质代谢和磷脂代谢机制研究

代表论文:(#第一作者,*通讯作者)

  1. 1. 1. Wenguang Chang#, Li Chen, *Grant M. Hatch. Berberine treatment attenuates palmitate-induced insulin resistance through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes.Biochimica et Biophysica Acta-molecular and cell biology of lipids. 2016 Jan 7;1861(4):352-362. doi: 10.1016/j.bbalip.2015.12.017.

  2. 2. 2. Hieu M. Nguyen, Edgard M. Mejia,Wenguang Chang, Ying Wang, Emily Watson, Ngoc On, *Donald W. Miller and *Grant M. Hatch. Cardiolipin regulates mitochondrial spare respiratory capacity and glucose transport into and across human brain cerebral microvascular endothelial cells.Journal of Neurochemisty. 2016 Jul 29. doi: 10.1111/jnc.13753.

  3. 3. 3. Wenguang Chang#,Ming Zhang, Zhaojie Meng, Yang Yu, Fan Yao; Grant M Hatch; *Li Chen. Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5'-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells.European Journal of Pharmacology. 2015 Oct 29. pii: S0014-2999(15)30324-1. doi: 10.1016/j.ejphar.2015.10.043.

  4. 4. 4. Wenguang Chang#, Kun Li, Fengying Guan, Fan Yao, Yang Yu, Ming Zhang, Grant M Hatch, *Li Chen. Berberine pretreatment confers cardioprotection against ischemia reperfusion injury in a rat model of type 2 diabetes.Journal of Cardiovascular Pharmacology and Therapeutics. 2016 Feb 4. pii: 1074248415627873.

  5. 5. 5. Wenguang Chang#, Li Chen, *Grant M Hatch. Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies.Biochemistry and Cell Biology.2015, 93(5): pp. 479-486.doi: 10.1139/ bcb-2014-0107.

  6. 6. 6. Wenguang Chang#, Ming Zhang, Zhaojie Meng, Dong Xiao, Shengnan Wei, *Li Chen, Chunyan Wang, Grant M Hatch. Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat Heart.Cardiovasular Drugs and Therapy. 2012, Dec; 26(6):467-78. doi: 10.1007/s10557-012-6422-0.

  7. 7. 7. Wenguang Chang#, Ming Zhang, Jing Li, Zhaojie Meng, Shengnan Wei, Hongwei Du, *Li Chen, Grant M. Hatch. Berberine improves insulin resistance in cardiomyocytes via activation of 5’-adenosine monophosphate-activated protein kinase.Metabolism.2013, Aug; 62(8):1159-67. doi: 10.1016/j.metabol.2013.02.007.

  8. 8. 8. Ming Zhang, Xiaoyan Lv, Jing Li, Zhaojie Meng, Qingjing Wang,Wenguang Chang, Wei Li, *Li Chen, Yanjun Liu. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis.Molecular and Cellular Endocrinology.2012, 363(1-2):122-30. doi: 10.1016/ j.mce.2012.08.006.

  9. 9. 9. Zhaojie Meng, Xueying Bao, Miing Zhang, Shengnan Wei,Wenguang Chang, Jing Li, *Li Chen, B.L.Gregoire Nyomba. Alteration of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor by ethanol in rat liver and mouse hepatoma cells.Journal of Diabetes Research.2013, 2013:218102. doi: 10.1155/2013/218102.

  10. 10.10. Lei Ji, Yingying Liu , Ying Zhang,Wenguang Chang, Junli Gong, Shengnan Wei, Xudong Li, *Ling Qin. The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high glucose-induced injured H9c2 cardiomyoblasts. CanadianJournal of physiology and pharmacology. 2016 Sep;94(9):996-1006. doi: 10.1139/cjpp-2015-0587.

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